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10.1002/eji.201746939

The permeability of the leak pathway can be better assessed ex vivo by measuring the flux of molecules from the luminal to the basolateral side such as EDTA, mannitol, sucrose, inulin and polyethylene glycols (PEG) or dextran molecules of variable sizes (ranging from 4 up to 20 KDa)

In the present study, NO plasma levels were found to be increased after exercise, in accordance with other reports, which show that iNOS activity and NO release are increased with exercise in several tissues [36, 37]

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Additionally, acetylcysteine engages in direct chemical scavenging of reactive oxygen species and disrupts disulfide bridges in mucoprotein structures, promoting mucolytic activity

At nanomolar concentrations (1 to 10 nM), it stimulates collagen, glycosaminoglycan, and proteoglycan synthesis in dermal fibroblasts